Skip directly to content

El Descubrimiento del inhibidor de JAK

Martes, Febrero 7, 2017
Dr. Mark E. Flanagan


Xeljanz. Highlights for Prescribing information 2012. Pfizer Labs.

Witthuhn et al (1994). Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370, 153 – 157.

Vijayakrishnan L  et al .Treating inflammation with the Janus kinase inhibitor CP-690,550. Trends Pharmacol Sci. 32(1):25-34.

van Vollenhoven RF (2009). Treatment of rheumatoid arthritis: state of the art 2009. Nat Rev Rheumatol. 5(10):531-41.

Taskén K & Aandahl EM (2004). Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev. 84(1):137-67.

Shuai K & Liu B (2003). Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 3(11):900-11.

Schett, G. et al (2008). How antirheumatic drugs protect joints from damage in rheumatoid arthritis. Arthritis & Rheumatism, 58: 2936–2948.

Sanjabi S (2009).  Anti- and Pro-inflammatory Roles of TGF-β, IL-10, and IL-22 In Immunity and Autoimmunity. Curr Opin Pharmacol.  9(4): 447–453. doi:10.1016/j.coph.2009.04.008

Rommel C &Camps M, Ji H (2007). PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol. 7(3):191-201.

Qiu Y & Kung H. (2000). Signaling network of the Btk family kinases. Oncogene 19, 5651 ± 5661

O’Shea JJ (2013). JAKs and STATs in Immunity, Immunodeficiency, and Cancer. N Engl J Med 368;2

O’Sullivan et al (2007). Cytokine receptor signaling through the Jak–Stat–Socs pathway in disease. Molecular Immunology 44 2497–2506.

Milici A et al (2008). Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis. Arthritis Research & Therapy 10:R14 (doi:10.1186/ar2365).

Meyer et al (2010). Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. Journal of Inflammation 2010, 7:41.

McInnes I. & Schett G (2007). Cytokines in the pathogenesis of rheumatoid arthritis. Nature Review.

McInnes I (2011). The Pathogenesis of Rheumatoid Arthritis. N Engl J Med.365:2205-19

McInnes I & Liew F ( 2005). Cytokine networks—towards new therapies for rheumatoid arthritis. Nature Clinical Practice. VOL 1  No 1.

Mavers et al (2009). Intracellular Signal Pathways: Potential for Therapies. Curr Rheumatol Rep. 11(5): 378–385.

Kontzias A et al (2012). Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease. Current Opinion in Pharmacology. 12:464–470